The hypoxia-lactate axis tempers inflammation
WebThe hypoxia-lactate axis tempers inflammation. Nat Rev Immunol. 2024;20(2): 85 – 86. doi: 10.1038/s41577-019-0259-8 , , [Web of Science ®], [Google Scholar] Liu N, Luo J, Kuang D, et al. Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α-mediated tumor progression. J Clin Invest. WebNov 10, 2024 · Lactate, a byproduct of glycolysis, is a vital signal determining inflammation. Lactate can inhibit inflammatory responses by blocking pro-inflammatory signaling pathways. In addition, lactate exerts anti-inflammatory effects by promoting the polarization of M2 macrophages after modification of histone lactylation. ... The hypoxia-lactate axis ...
The hypoxia-lactate axis tempers inflammation
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WebFeb 1, 2024 · Hypoxia occurs in many disease states including tumours, infections, ischaemia and inflammation. The activation of innate immune cells by inflammatory … WebOct 1, 2024 · The hypoxia–lactate axis tempers inflammation. Nat. Rev. Immunol., 20 (2) (2024), pp. 85-86. CrossRef View in Scopus Google Scholar [63] V. Kumar, R. Rani. Selective Inhibitors of human Lactate dehydrogenase A to fight against metabolic cancer: a patent landscape. Patent analyst, 9 (6) (2024) 2024-0025.
WebMy Research and Language Selection Sign into My Research Create My Research Account English; Help and support. Support Center Find answers to questions about products, … WebJul 1, 2024 · In this review, we provide an insight into the role of lactate, succinate, fatty acids, amino acids as well as ketogenesis-derived and β-oxidation-derived intermediates as extracellular signalling molecules. Moreover, the mechanisms by which their cognate metabolite-sensing GPCRs integrate nutritional and metabolic signals with specific ...
WebINFLAMMATION IN 2024 The hypoxia–lactate axis tempers inflammation Lionel B. Ivashkiv Hypoxia and glycolysis have long been appreciated to promote immune cell activation. WebAug 4, 2024 · The hypoxia–lactate axis tempers inflammation. Nat Rev Immunol. 2024;20(2):85–6. Article CAS PubMed PubMed Central Google Scholar Corbet C, Feron O. Tumour acidosis: From the passenger to the driver's seat. Nat Rev Cancer. 2024;17(10):577–93. Article CAS PubMed ...
WebDec 9, 2024 · Hypoxia occurs in many disease states including tumours, infections, ischaemia and inflammation. The activation of innate immune cells by inflammatory …
WebAug 7, 1999 · High blood lactate concentration (hyperlactacidaemia) in trauma or sepsis is thought to indicate tissue hypoxia and anaerobic glycolysis even when blood pressure, … thumb ucl tear radsourceWebFeb 26, 2024 · The hypoxia-lactate axis tempers inflammation. Nat Rev Immunol 2024;20:85–6. Crossref. PubMed. Google Scholar. 128. Colegio OR, Chu NQ, Szabo AL, Chu T, Rhebergen AM, Jairam V, Cyrus N, Brokowski CE, Eisenbarth SC, Phillips GM, Cline GW, Phillips AJ, Medzhitov R. Functional polarization of tumour-associated macrophages by … thumb ucl sprain exercisesWebDec 22, 2024 · A number of studies are devoted to the role of lactate in the development of inflammation. It has been shown that GPR81 expression in adipocytes and endothelial cells decreases under inflammatory conditions. ... Ivashkiv LB (2024) The hypoxia-lactate axis tempers inflammation. Nat Rev Immunol 20(2): 85–86. thumb ucl repairWebDec 24, 2024 · The hypoxia–lactate axis tempers inflammation Studies in the field of inflammation in 2024 have highlighted a counterbalancing homeostatic function for the glycolytic metabolite lactate,... thumb ucl repair therapy protocolWebFeb 28, 2024 · Under the condition of hypoxia, glucose catabolism is mainly carried out through the inefficient energy metabolism pathway glycolysis to produce a large amount of lactate, a.k.a., the Warburg effect, one of the hallmarks of tumors, which makes large amounts of lactate and generates an acidic tumor microenvironment [ 21 ]. thumb ucl sprain rehab protocolsWebHypoxia occurs in many disease states including tumours, infections, ischaemia and inflammation. The activation of innate immune cells by inflammatory factors and … thumb ucl sprain symptomsWebMar 13, 2024 · Necrotizing Enterocolitis (NEC) is characterized by an inflammation of intestinal tissue that primarily affects premature infants. It is the most common and devastating gastrointestinal morbidity of prematurity, but beyond intestinal morbidity, this condition has also been associated with an increased risk of neurodevelopmental delays … thumb ucl tear orthobullets