Rhizopodin
TīmeklisThe C1–C15 fragment of rhizopodin was synthesized through either Suzuki coupling reaction of vinyl iodide and vinyl boronate or cross-metathesis of a terminal olefin and a diene adduct in the presence of Hoveyda–Grubbs II catalyst. Key words cross-metathesis - cross-coupling - stereocontrolled synthesis - conjugated diene - … TīmeklisSymmetry helps: The total synthesis of the potent actin-targeting C 2-symmetric myxobacterial macrolide rhizopodin (see scheme) is accomplished by the convergent assembly of three building blocks of similar complexity, a concise macrocyclization strategy, and a late-stage introduction of the labile side chains.
Rhizopodin
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TīmeklisScipio is used for the retrieval of the genome sequence corresponding to a protein query. The tool does not require any annotation data, and is able to correctly identify the gene even if this is spread on several genome contigs and contains mismatches and frameshifts. Because of its post-processing capabilities, Scipio is not only able to … TīmeklisSymmetry helps: The total synthesis of the potent actin-targeting C 2-symmetric myxobacterial macrolide rhizopodin (see scheme) is accomplished by the …
TīmeklisRhizopodin is a natural compound that strongly affects the actin cytoskeleton at nanomolar concentrations. Initial work revealed interesting anti-bacterial and cytotoxic effects, but the cellular effects and pharmacological properties of rhizopodin have not been characterized. We hypothesized that rhizopodin might exert anti-cancer activity. TīmeklisRhizopodin was isolated as cytostatic and weakly antifungal macrolide (1) and later characterized as potent actin-depolymerizing agent. It is produced by the myxobacterium Myxococcus stipitatus, which enables a fermentative supply of the drug for biological studies. We here report a revised structure that characterizes rhizopodin (2) as the …
Tīmeklis2015. gada 29. janv. · The natural products rhizopodin and bistramide belong to an elite class of highly potent actin binding agents. They show powerful antiproliferative … Tīmeklis2024. gada 25. okt. · Rhizopodin (3) is an architecturally complex macrocyclic polyketide first isolated in 1993 by Reichenbach and co-workers 66 from the myxobacterium …
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Tīmeklis有道首页 - 关于有道 - 官方博客 © 2011 网易公司 京icp证080268号 chordettes singing groupTīmeklis2013. gada 10. okt. · Rhizopodin was obtained and fully characterized. Abstract A highly convergent total synthesis of the potent … chord e on guitarTīmeklisConfigurational Assignment of Rhizopodin, an Actin-Binding Macrolide from the Myxobacterium Myxococcus stipitatus Nicole Horstmann‡ and Dirk Menche*,†,‡ † University of Heidelberg, Department of Organic Chemistry, INF 270, D-69120 Heidelberg, Germany and ‡ Helmholtz Centre for Infection Research (HZI), Medicinal … chord energy corporation chrdTīmeklisA stereoselective assembly of the C9−C23 (C9′−C23′) fragment of rhizopodin, a 38-membered bis-lactone natural product, has been developed. A highly efficient approach to this fragment assembles >50% of the carbon skeleton and the stereochemical elements present in the natural product. chordeleg joyeriasTīmeklis2024. gada 24. janv. · Actin-associated proteins (AAPs) act on monomeric globular actin (G-actin) and polymerized filamentous actin (F-actin) to regulate their dynamics and architectures which ultimately control cell movement, shape change, division; organelle localization and trafficking. Actin-binding proteins (ABPs) are a subset of AAPs. … chord everything i wantedTīmeklis2012. gada 25. janv. · By matching with our in-house database of myxobacterial secondary metabolites, this compound was identified as rhizopodin. A detailed … chord energy investor presentationTīmeklis2008. gada 29. sept. · Rhizopodin was isolated as cytostatic and weakly antifungal macrolide (1) and later characterized as potent actin-depolymerizing agent. It is … chord face to face