Irf3 phosphorylation site
WebWe show that both MAVS and STING are phosphorylated in response to stimulation at their respective C-terminal consensus motif, pLxIS (p, hydrophilic residue; x, any residue; S, …
Irf3 phosphorylation site
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WebNational Center for Biotechnology Information WebSep 15, 2024 · Importantly, it was discovered that UL13 phosphorylates IRF3, and its kinase activity is indispensable for such an inhibitory effect. Moreover, UL13 does not affect IRF3 dimerization, nuclear translocation or association with CREB-binding protein (CBP) but attenuates the binding of IRF3 to the IRF3-responsive promoter.
WebApr 12, 2024 · The synergy between Jmjd8 knockdown and etoposide in regard to TBK1 and IRF3 phosphorylation, type I IFN and ISGs expression, and cytotoxicity was also seen in 4T-1 cells (Figures 6E–6H and S6D). We next injected nude mice subcutaneously with control or JMJD8-knockdown MCF7 cells and treated mice with or without etoposide. WebHere we define GnT interactions and residues required to inhibit TRAF3-TBK1 directed IFNβ induction and IRF3 phosphorylation. We observed that GnTs bind TRAF3 via residues within the TRAF-N domain (392-415) and that binding is independent of the MAVS interactive TRAF-C domain (415-568). We determined that GnT binding to TRAF3 is mediated by C ...
WebIRF3 is activated through a two-step phosphorylation in the C-terminal domain mediated by TBK1 and/or IKKi, requiring Ser386 and/or Ser385- site 1; and a cluster of serine/threonine … WebPhosphorylated S366 is a docking site for IRF3 and is essential for the subsequent induction of Interferons (IFNs) (7, 8). ... Therefore, in addition to its effect on IRF3 phosphorylation, …
WebMay 27, 2016 · We report that HSV-1 inhibits the STING–TBK1–IRF3 pathway by directing ICP27 to the activated STING–TBK1 signalsome, thus preventing phosphorylation and activation of the transcription factor IRF3 (Appendix Fig S5). Macrophages are often resident at or recruited to sites of viral infection, but are rarely the major source of viral production.
WebJan 19, 2024 · We wondered whether pyrophosphorylation of IRF3 at S386 serves as a signal for subsequent multi-site phosphorylation. We found that knockdown of UAP1 or … how are scratch tickets madeWebJul 30, 2015 · The N-terminus of TRIF recruits TRAF-3 and phosphorylates IRF3, leading to the induction of type-1 IFN [12,13] ... To date, 12 putative p65 phosphorylation sites have been identified . Among them, five sites (Ser205, Ser276, Ser281, Ser311 and Thr264) are located in the N-terminal Rel homology domain (RHD) and the remaining seven (Ser468 ... how many miles is 6.3 kmWebViral infection results in phosphorylation of IRF3, leading to its translocation to the nucleus, where it activates promoters containing IRF3-binding sites. Phosphorylation of IRF3 … how are scottish islands formedWebIt is now well established that TBK1 is responsible for IRF3 phosphorylation in response to stimulation of several intracellular receptors that induce type-I interferons, including TLR3, … how many miles is 6650 kilometersWebMar 23, 2001 · Kinetics of IRF phosphorylation. A, kinetics of IRF7 phosphorylation. 293T cells transfected with 10 μg of an IRF7 expression construct were infected with NDV 12 h later, and nuclear extracts harvested at the indicated times post-infection were analyzed for IRF7 phosphorylation by SDS-PAGE and immunoblotting. B, kinetics of IRF3 … how many miles is 6.8WebJul 14, 2016 · IRF3 phosphorylation inhibitor BX 795 was prepared with DMSO to 10 mM stock. IRF3 siRNA (h), IRF7 siRNA (h) and control siRNA-A were supplied by Santa Cruz Biotechnologies. how are screwdrivers sizedWebInterferon regulatory factor 3 Show on y-axis -References (HTP + LTP) References (LTP) References (HTP) log2 Transformation. Filter PTM sites. Minimum 5 References Add … how are screwdriver handles made