TPS3619 Background: Approximately 10% of patients (pts) with mCRC have BRAF mutations (mostly V600E). 1L tx options for BRAFV600E mCRC are limited to cytotoxic chemotherapy ± anti-VEGF or anti-EGFR, or immune checkpoint inhibitors in pts with MSI-H tumors. In Europe, Japan, and USA, the combination of BRAF inhibitor enco + EGFR inhibitor cetux is approved for tx of BRAFV600E mCRC after prior ... WebFeb 25, 2024 · breakwater ( plural breakwaters ) A construction in or around a harbour designed to break the force of the sea and to provide shelter for vessels lying inside. ( nautical) A low bulkhead across the forecastle deck of a ship which diverts water breaking over the bows into the scuppers. (on beaches) A wooden or concrete barrier, usually ...
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